Continuation

The second part of the study will involve 2 groups of patients with severe GD allocated to either receiving 2 infusions of low dose Daratumumab or placebo (saline) 2 weeks apart. Conventional treatment with antithyroid tablets and eye treatment will continue in both groups.  The main aim of this study is to determine how effectively Daratumumab can reduce TRAb levels.

Questions:      Please state your views about these statements: consider how you would feel if this study was being offered to you today. 

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* 1. I would volunteer for the study only if my own specialist doctor (endocrinologist or ophthalmologist) suggested it.

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* 2. A 50% chance of receiving the placebo and not Daratumumab would put me off participating in the study.

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* 3. That this study is looking at a new way to successfully treat severe Graves’ disease with the potential to avoid invasive surgery in future would encourage me to participate.

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* 4. The fact that high dose Daratumumab is used to treat a type of blood cancer worries me about its side effects

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* 5. The fact that the dose of Daratumumab given in this study is very low, and given only twice compared to the high and regular doses used in a form of blood cancer, reassures me about the potential side effect profile of Daratumumab in this study

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* 6. If the results of this study is positive and I was given a choice between Daratumumab infusion and conventional treatment for severe Graves’ disease (thyroid and eye surgery), I would definitely consider choosing Daratumumab instead

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* 7. If I could choose the treatment for my Graves’ disease, I would prefer thyroid surgery to two 3hr infusions of a medicine (please indicate on the line below your preference with a cross).

Thyroid surgery Infusion of medicine
i We adjusted the number you entered based on the slider’s scale.

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* 8. If I could choose the treatment for my thyroid eye disease, I would prefer eye surgery to two 3hr infusions of a medicine (please indicate on the line below your preference with a cross).

Eye  surgery Infusion of Medicine
i We adjusted the number you entered based on the slider’s scale.

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