Copy of Unmet clinical needs in paediatric asthma

Unmet needs in the diagnosis and management of paediatric asthma

A SHORT (LESS THAN 3 MINUTES) SURVEY TO PRIORITISE UNANSWERED QUESTIONS IN THE DIAGNOSIS AND MANAGEMENT OF PAEDIATRIC ASTHMA.

Did you have asthma as a child?

Do you or did you care for a child with asthma?

Diagnosis and management of asthma in children is not optimal. The PaEdiatric Asthma in Real Life (PeARL) is a group of experts in childhood asthma, aiming to identify gaps of our understanding of asthma in childhood and to promote high-quality research projects that will address these gaps in our knowledge and improve the care that children with asthma receive.

Please help us shape future research and practice in childhood asthma by completing the following short survey. It should take no more than 3 minutes of your time.

Thank you very much in advance,

The PeARL group.

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* 1. DIAGNOSIS, CLASSIFICATION AND PROGRESSION OF ASTHMA. Which of the following issues should we tackle in order to improve the lives of children with asthma? (select 2-5 responses).

Which are the most accurate diagnostic tests?

What is the simpler way to confidently diagnose asthma in children?

How can we predict whether asthma will have permanent effects in the lungs later in the life?

Using available treatments, can we prevent the long-term impact of asthma on children's health?

Do we need to treat differently children with co-existing allergy?

How should we group children by age, in order to deliver the most appropriate management?

How important is to assess for and treat other medical problems that children frequently have?

Do we need a personalised approach to the diagnosis of asthma, in children with different asthma subtypes?

In children not experiencing asthma symptoms any more, how can we confirm that asthma is in remission?

How can we predict the progression of asthma in adulthood and its future severity?

Can we identify different subtypes of asthma in children, that may require different treatments (so-called phenotyes or endotypes).

What factors cause or predict the development of severe, very symptomatic asthma?

How does continuous exposure to pollution, smoking, infections and other factors impacts asthma progression and outcomes?

Other (please specify)

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* 2. ASSESSMENT: Which of the following are the two most important unanswered questions? (Select 1-3 responses)

How can we evaluate asthma control in different age groups?

What blood tests provide important information about the diagnosis, management and future risk of deterioration in childhood asthma?

How can we accurately interpret patients' descriptions of their disease and symptoms?

How can we evaluate asthma severity in different age groups?

What is the role of bronchoscopy (camera tests looking in the lungs) and of receiving tissue samples in childhood ashtma?

What are the cut-point values that reveal abnormal results in breathing tests in different age gropus?

Other (please specify)

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* 3. MONITORING: Which of the following are the two most clinically-important unanswered questions? (Select 1-3 responses)

Home lung function monitoring

How should we monitor asthma control? At what intervals?

Telemonitoring and eDiaries

School monitoring

Systemic or airway inflammation monitoring

Safety monitoring (height, osteoporosis monitoring)

HRCT (detailed lung scans) in children with limited reversibility

Other (please specify)

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* 4. DRUG TREATMENT OF CHILDHOOD ASTHMA: Which of the following are the two most important unanswered questions? (Select 2-6 responses)

How can we prevent the permanent damage that asthma may cause to the airways?

Development of simple algorithms to standardise and improve the management of asthma in chilfen

Can some children be managed only with biologic treatments?

What should clinicians aim for when treating children with asthma?

Many children now have only one inhaled medication to use every day, regularly, but also when they are poorly. What direct evidence from children studies support this approach?

How can we deliver personalised treatments for people with different asthma subtypes (phenotypes and endotypes)?

What advise should we give to children and their parents regarding how to manage increased asthma symptoms themselves, before having to see a doctor?

What is the role of regular use of steroid tablets

What is the role of immunotherapy in children with ashtma? Immunotherapy is proved to be effective in some cases, but is also associated with side effects.

What is the role of strong biologic treatments (which however may have side effects) in the treatment of children with asthma? When should we really consider them?

How can we decide whether children require regular treatment for their asthma? (how severe disease? what age?)

What is the most effective and simple to use in children inhaler device?

How can we assess whether children are using their inhalers correctly and regularly? (By not doing so, they are not getting adequate treatment)

Asthma treatments have side effects. When should we consider stopping some of the treatments children receive for their asthma (because they may not need them anymore)?

What evidence supports the use of different medications in children of different ages? (direct evidence from children studies, in contrast with indirect evidence from studies in adults, which may not have the same response to some medications).

Other (please specify)

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* 5. NON-DRUG MANAGEMENT: Which of the following are the two most important unanswered questions? (Select 1-3 responses)

What is the role of vaccination in asthma management

What is the role of nutritional supplements (probiotics, prebiotics, symbiotics, bacterial lysates, antioxidants, vitamins, etc.) in asthma management

What is the role of smoking cessation programmes for parents in asthma management

What is the role of diet in asthma management

What is the role of e-health(electronic) & m-health(mobile) in asthma management

What is the role of educational programmes in asthma management

What is the role of exercise and physiotherapy in asthma management

What is the role of psychological support/treatment in asthma management

What is the role of balneo- and climatotherapy (spa, sanatoria etc) in asthma management

What is the role of the avoidance of allergens in asthma management

What is the role of community support (family, school, etc) in asthma management

Other (please specify)

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* 6. OTHER QUESTIONS: Which of the following are the two most important unanswered questions? (Select 1-3 responses)

What is the frequency of childhood asthma and what burden does it cause to patients and the society

Who should be referred for specialist diagnostic assessment?

What is the “cultural” meaning of asthma in different communities?

Does the presentation and management of asthma vary based on ethnicity and/or race

When and how to refer for allergy testing?

Other (please specify)

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* 7. What best describes your role?

Clinician

Clinical Researcher

Family member/ Caretaker of a patient with paediatric asthma

I have/had childhood asthma

Pharma researcher/employee

Organisations / Regulators

Scientist

Copy of Unmet clinical needs in paediatric asthma

Unmet needs in the diagnosis and management of paediatric asthma

Question Title

* 1. DIAGNOSIS, CLASSIFICATION AND PROGRESSION OF ASTHMA. Which of the following issues should we tackle in order to improve the lives of children with asthma? (select 2-5 responses).

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* 2. ASSESSMENT: Which of the following are the two most important unanswered questions? (Select 1-3 responses)

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* 3. MONITORING: Which of the following are the two most clinically-important unanswered questions? (Select 1-3 responses)

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* 4. DRUG TREATMENT OF CHILDHOOD ASTHMA: Which of the following are the two most important unanswered questions? (Select 2-6 responses)

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* 5. NON-DRUG MANAGEMENT: Which of the following are the two most important unanswered questions? (Select 1-3 responses)

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* 6. OTHER QUESTIONS: Which of the following are the two most important unanswered questions? (Select 1-3 responses)

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* 7. What best describes your role?

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* 8. In what country do you work?

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* 9. E-mail Address

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* 10. Name, Surname (Optional)