NHGRI-EBI GWAS Catalog
Inclusion of association results

The GWAS Catalog includes both curated associations (significant independent associations only) and summary statistics (p-values of all variants in the discovery GWAS). The curated associations are available via our web-based search interface, whereas summary statistics files are available to download via our ftp.

In this questionnaire, we are focusing on the curated part of the Catalog.

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Figure 1: GWAS study design showing discovery and replication stages

The curated GWAS Catalog includes associations that meet statistical significance (p-value <1.0 x 10^-5) in either:

1. the discovery GWAS stage if no replication was performed
OR
2. the combined (discovery GWAS + replication) analysis

In each of these cases the most significant SNP from each independent locus is extracted.

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* 1. Are you happy with the curated content of the Catalog?

Yes

Somewhat

If you answered no or somewhat please provide additional details

Thinking about studies that include a replication stage

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* 2. What associations would you like to see in the Catalog? Rank from 1 (highest preference) to 3 (lowest preference).

All significant independent associations from discovery stage with no replication information

Only independent associations from the discovery stage that have also been replicated.
Significant associations from the discovery that were not attempted for replication would not be included.

All significant independent associations from discovery stage with additional information to indicate which associations have been replicated

Thinking about how you would like to see replication information presented, please consider the following options (described further in question 6, below):

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Table 1: Options for presenting replication information

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* 3. Please rate how useful you would find each of the following options (illustrated in Table 1 above).

	Not useful at all	Slightly useful	Useful	Extremely useful
A. Discovery p-value plus a flag to indicate associations that have been successfully replicated	A. Discovery p-value plus a flag to indicate associations that have been successfully replicated Not useful at all	A. Discovery p-value plus a flag to indicate associations that have been successfully replicated Slightly useful	A. Discovery p-value plus a flag to indicate associations that have been successfully replicated Useful	A. Discovery p-value plus a flag to indicate associations that have been successfully replicated Extremely useful
B. Option A (discovery plus replication flag) with details of replication sample (metadata)	B. Option A (discovery plus replication flag) with details of replication sample (metadata) Not useful at all	B. Option A (discovery plus replication flag) with details of replication sample (metadata) Slightly useful	B. Option A (discovery plus replication flag) with details of replication sample (metadata) Useful	B. Option A (discovery plus replication flag) with details of replication sample (metadata) Extremely useful
C. Combined (discovery+replication) p-value only	C. Combined (discovery+replication) p-value only Not useful at all	C. Combined (discovery+replication) p-value only Slightly useful	C. Combined (discovery+replication) p-value only Useful	C. Combined (discovery+replication) p-value only Extremely useful
D. Discovery p-value plus combined p-value	D. Discovery p-value plus combined p-value Not useful at all	D. Discovery p-value plus combined p-value Slightly useful	D. Discovery p-value plus combined p-value Useful	D. Discovery p-value plus combined p-value Extremely useful
E. Discovery p-value plus replication p-value	E. Discovery p-value plus replication p-value Not useful at all	E. Discovery p-value plus replication p-value Slightly useful	E. Discovery p-value plus replication p-value Useful	E. Discovery p-value plus replication p-value Extremely useful
F. Discovery p-value plus both replication p-value and combined p-values	F. Discovery p-value plus both replication p-value and combined p-values Not useful at all	F. Discovery p-value plus both replication p-value and combined p-values Slightly useful	F. Discovery p-value plus both replication p-value and combined p-values Useful	F. Discovery p-value plus both replication p-value and combined p-values Extremely useful

Please add any additional comments

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* 4. In your opinion, which is more important for the GWAS Catalog to include?

All independent significant associations from the discovery stage

Only independent significant associations that are successfully replicated

Please provide additional information on why you made this choice (optional)

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* 5. Please provide any additional comments on which associations you would like to see in the GWAS Catalog

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50% of survey complete.