Intrauterine hCG administration prior to embryo transfer
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A recent Cochrane review suggests that intracavity human chorionic gonadotropin (IC-hCG) at a dose of 500 IU or greater improved clinical pregnancy (RR 1.49, 95% CI 1.32 to 1.68) and live birth rates (RR 1.57, 95% CI 1.32 to 1.87) for cleavage-stage transfers. Given the strength of the evidence, the authors recommended that this intervention can be incorporated into clinical practice. Current evidence for IC-hCG treatment does not support its use for blastocyst transfers. The review authors found no evidence that miscarriage was influenced by IC-hCG administration, irrespective of embryo stage at transfer or dose of IC-hCG. Events were too few to allow any conclusions to be drawn with regard to other complications.(Link to Full Review)
We are conducting a short survey to investigate the professionals' views on this novel intervention.