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A recent Cochrane review suggests that intracavity human chorionic gonadotropin (IC-hCG) at a dose of 500 IU or greater improved clinical pregnancy (RR 1.49, 95% CI 1.32 to 1.68) and live birth rates (RR 1.57, 95% CI 1.32 to 1.87) for cleavage-stage transfers. Given the strength of the evidence, the authors recommended that this intervention can be incorporated into clinical practice. Current evidence for IC-hCG treatment does not support its use for blastocyst transfers. The review authors found no evidence that miscarriage was influenced by IC-hCG administration, irrespective of embryo stage at transfer or dose of IC-hCG. Events were too few to allow any conclusions to be drawn with regard to other complications.(Link to Full Review)
We are conducting a short survey to investigate the professionals' views on this novel intervention.

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* 1. Which of the following best describes your job role?

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* 2. Are you employed in :

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* 3. Based on the recent Cochrane Review, are you considering applying IC-hCG treatment to clinical practice within the next 6 months?

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* 4. If you are not likely to apply IC-hCG to your practice, why not?

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* 5. Would evidence from a UK multicentre randomised trial impact on your likelihood to incorporate the intervention into your clinical practice?

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* 6. Would you be willing to recruit patients to a multicentre trial of intrauterine hCG versus standard care for fresh cleavage stage transfers?

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* 7. Would you be willing to recruit patients to a multicentre trial of intrauterine hCG versus standard care for fresh blastocyst transfers?

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* 8. Would you be willing to recruit patients to a multicentre trial of intrauterine hCG versus standard care for frozen-thawed cleavage stage transfers?

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* 9. Would you be willing to recruit patients to a multicentre trial of intrauterine hCG versus standard care for frozen-thawed blastocyst transfers?

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* 10. Please add any additional comments in the text box below

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