Question Title

In 2021, the new ESC/EACTS Guidelines included TAVI as Class IA in all severe aortic stenosis (sAS) patients ≥75 years.1 What major Edwards Lifesciences’ clinical trial had contributed to this change?2

1 Vahanian A, et al. Eur Heart J. 2021; ehab395. doi:10.1093/eurheartj/ehab395.
2 Mack MJ, Leon MB, Thourani VH, et al. N Engl J Med. 2019;380(18):1695-1705.

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